Prolia stays in a patient’s system for only a finite period of time, and Siris says this reversibility could be one appeal. “At the end of six months, if you don’t get another dose, it’s gone. So if you felt you didn’t want to use this approach, it’s gone after the six months after the dose is given. It doesn’t linger in the bone for extended periods, which some people have worried about in the past. Bisphosphonates linger in bone long after you stop them, whereas this [drug] is gone in six months,” explains Siris.
An acute myopathy has been observed with the use of high doses of corticosteroids, most often occurring in patients with disorders of neuromuscular transmission (eg, myasthenia gravis ), or in patients receiving concomitant therapy with neuromuscular blocking drugs (eg, pancuronium). This acute myopathy is generalized, may involve ocular and respiratory muscles, and may result in quadriparesis . Elevation of creatinine kinase may occur. Clinical improvement or recovery after stopping corticosteroids may require weeks to years.