like a river, fashion will break free with overwhelming fluidity becoming the principle of design for the near future. the fluency of the currents and waves and rapids and rivulets is reflected in the fluidity of folds and drapes and smocks and gathers, while froth and foam are rendered with fine pleating, layering and perforation. cascading waterfalls of frills and ruffles will give majestic form to romanticism. breaking waves of fine foamy jerseys will be layered to shield from a sudden summer breeze. the wilder currents of the ocean will stand for conceptual asymmetrical shapes while the stillness of the lake will ripple softly with crêpe and undulating yarns, reflective and minimal in a profound and deep dark blue.
Oral curcumin administration has been found to inhibit the development of chemically-induced cancer in animal models of oral (58, 59) , stomach (60, 61) , liver (62) , and colon (63-65) cancer. Apc Min/+ mice have a mutation in the Apc (adenomatous polyposis coli) gene similar to that in humans with familial adenomatous polyposis , a genetic condition characterized by the development of numerous colorectal adenomas ( polyps ) and a high risk for colorectal cancer . Oral curcumin administration has been found to inhibit the development of intestinal adenomas in Apc Min/+ mice (66, 67) . Despite promising results in animal studies, there is presently little evidence that high intakes of curcumin or turmeric are associated with decreased cancer risk in humans. A 30-day phase II clinical trial in 40 smokers with at least eight rectal aberrant crypt foci (ACF; precancerous lesions) found that the number of ACF was significantly lower with a daily supplementation with 4 g/day of curcumin compared to 2 g/day (68) . Several controlled clinical trials in humans designed to evaluate the effect of oral curcumin supplementation on precancerous colorectal lesions, such as adenomas, are under way (69) .