More recently, androgen receptors have been shown to have a second mode of action. As has been also found for other steroid hormone receptors such as estrogen receptors , androgen receptors can have actions that are independent of their interactions with DNA.   Androgen receptors interact with certain signal transduction proteins in the cytoplasm. Androgen binding to cytoplasmic androgen receptors can cause rapid changes in cell function independent of changes in gene transcription, such as changes in ion transport . Regulation of signal transduction pathways by cytoplasmic androgen receptors can indirectly lead to changes in gene transcription, for example, by leading to phosphorylation of other transcription factors.
Before coming to Eindhoven, I studied metal craftsmanship at Ecole Boulle. This school teaches students the traditional French craft heritage. There, I learned to have a good vision in 3D, precise technical skills and an eye for quality. Some aspects of this education have remained strongly in my mind: as we were forging our own tools with a fire torch and a hammer, I designed my own tools -all laser cut in steel- to construct the ‘Regen’ garments and accessories. I also love all the little technical tricks that make crafts and techniques being so smart. And to conclude, I really enjoy the craftsman routine: spending time in an atelier, being physically active and focused, trying out different tools, making a mess, and having the greatest satisfactory feeling when all the products are finally done and the atelier is clean again.
What fascinates you about designing materials?
First of all I would say that I am a materialist and therefore, I like to touch and feel the matter. I like the weight, the texture and the smell of things. I feel connected to the materials because my senses can relate to them. I like the smell of Argon when I weld, the smell of sheep when I work with wool, the smell of latex when I work on ‘Regen’. All these details give an atmosphere to my days. Besides this, I am seeking unexpected outcomes from common materials. I enjoy playing with their limits, or combine them to extract possibilities they haven’t given yet. When I manage to get a surprising effect, then I feel that I have achieved my goal.
Can you describe your creative process?