My dad takes metformin for his diabetes (ok, so his entire side of the family takes it for diabetes— PCOS and diabetes run through out my family history) and he suggested that I start with 1 a day for 2 weeks and then work up to my 2 a day suggested dose after that. I have found that waiting for my meal to settle a little while (usually about 15-20 minutes really helped me to avoid a lot of discomfort. I already have bathroom “issues” (I tend to go A LOT; a very regulated 30 minutes after I put anything in my mouth) so by waiting it just kind of wrapped into my normal habit and seemed a lot less intense.
But not every side effect is a bad one. Some are downright welcome. Take finasteride . Introduced in 1992 to treat noncancerous enlargement of the prostate gland , it was found to regrow hair (and is marketed for that purpose under the name Propecia). Today, millions of men use a low dose of finasteride to treat male pattern baldness . Similarly, minoxidil , originally marketed as an oral tablet for high blood pressure , was found to grow hair in those using it. Today, as a topical lotion or foam, it is a popular over-the-counter remedy for baldness.