As Testosterone Propionate is, of course, Testosterone, it suffers from moderate aromatization which results in the Estrogenic side effects of bloating, water retention, elevated blood pressure (as a result of the bloating), and risks of gynecomastia. This soft and puffy look that bloating brings to the physique is generally undesirable for most users that wish to engage in cutting cycles or lean mass cycles. Therefore, Testosterone Propionate must be utilized with an aromatase inhibitor in order to disable the aromatase enzyme and eliminate the water retention effect of the Estrogen conversion, which should result in a harder looking physique without the soft puffiness. In doing so, Testosterone can successfully be utilized as a ‘hardening’ and cutting compound, as well as for lean mass gains. Some individuals prefer the water retention, convinced that it aids in protecting tissues and connective tissue from the stressors of heavy strength gains and heavy lifting, and therefore Testosterone is preferred as a bulking and strength gaining compound in this case. In any case, Testosterone is also an excellent compound for all-out bulking and strength gaining cycles, which is what its main use seems to be among bodybuilders and athletes. It is a very versatile compound that can provide the anabolic strength necessary for bulking phases.
Important Safety Information for VECTICAL ® (calcitriol) Ointment
Indication: VECTICAL ® Ointment is indicated for the topical treatment of mild to moderate plaque psoriasis in adults 18 years and older. Adverse Events: In controlled clinical studies, the most commonly reported adverse reactions (≥ 3%) were lab test abnormality, urine abnormality, psoriasis, hypercalciuria, pruritus, and skin discomfort. Warnings/Precautions: The maximum weekly dose should not exceed 200 g. Avoid contact with eyes, lips and face. VECTICAL ® Ointment should be used with caution in patients receiving medications known to increase the serum calcium level, such as thiazide diuretics and in patients receiving calcium supplements or high doses of Vitamin D. If aberrations in parameters of calcium metabolism are noted discontinue VECTICAL ® Ointment until these normalize. Avoid excessive exposure of VECTICAL ® Ointment treated areas to either natural or artificial sunlight.
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Abstract: Psoriasis is a common and difficult condition to treat. Corticosteroids and other agents are often used. Zinc pyrithione has been used for other related conditions. This study compares the use of combined micronized clobetasol propionate and zinc pyrithione (DermaZinc™ prescription strength) together VS control cream and generic clobetasol propionate alone. The one month study was double-blind controlled with treatments applied on either side of the body in a randomized fashion. There were 36 patients enrolled in the study. Of those, one was disqualified due to possible improper usage of the two test products DermaZinc™ Spray compounded with 50mg micronized Clobetasol Propionate VS generic Clobetasol Propionate, and three were disqualified due to substantial lapse of time between appointments. The psoriasis was examined for the following parameters: erythema, scaling, and thickness. The results demonstrate that the DermaZinc™ Spray compounded with 50mg micronized Clobetasol Propionate was significantly more effective than the generic clobetasol propionate alone for each parameter. In addition, the DermaZinc™ Spray compounded with 50mg micronized Clobetasol Propionate cleared lesions faster compared to generic Clobetasol Propionate. We conclude that there is a synergistic effect of using corticosteroids with zinc pyrithione in the treatment of psoriasis.